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The Phase 3 TRIUMPH-4 trial pushed these numbers even higher, with the 12 mg dose achieving 28.7% mean weight loss at 68 weeks

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Mechanistic studies have revealed that altered expression of iron metabolism-related proteins (including GPX4, FTH1, TfR1, and HO-1), accumulation of lipid peroxidation products, and disruption of antioxidant defense systems (particularly the Nrf2/GPX4 pathway) are central to ferroptosis progression in cardiac tissue